Corey-Fuchs Reaction. An aldehyde / ˈ æ l d ɪ h aɪ d / is a compound containing a functional group with the structure −CHO, consisting of a carbonyl center (a carbon double-bonded to oxygen) with the carbon atom also bonded to hydrogen and to an R group, which is any generic alkyl or side chain. This reagent allows this conversion to conveniently be carried out on a large scale under ambient conditions. The group—without R—is the aldehyde group, also known as the formyl group. Aldehyde-benzyl-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This two step methodology allows the preparation of terminal alkynes by one-carbon homologation of an aldehyde. The reaction map is intended to provide insight into possible reactions one step before and after the title reaction. IC 50 & Target: PEGs .

Some examples are enediynes (DNA-cleaving agents), ‘click chemistry’ tools and building blocks. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.

Consequently, it triggers a demand for efficient syntheses of alkynes. Its potential and widespread applications extend from organic synthesis through materials science to bioorganic chemistry. This reaction is the Ohira–Bestmann modification 1,2 of the Seyferth–Gilbert homologation. It also serves as an alternative way to navigate the website, and as a means of coming up with retrosynthetic ideas. 3,4.

Acetylene chemistry has been and remains an important constituent element of molecular sciences.

An convenient reagent for the one-carbon homologation of an aldehyde to the corresponding alkyne is reported. A novel synthetic route to polyquinolines with 6-substituted quinoline as the structural unit was developed based on the polymerization of alkyne–aldehyde monomers and aniline derivatives under the catalysis of Lewis acid B(C6F5)3.

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